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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10121 | Substance P Receptor Antagonist 1 | Others | |
Substance P Receptor Antagonist 1 has the potential function in gastrointestinal disorders, inflammatory diseases, respiratory, and central nervous system disorders. | |||
T1743 | Aprepitant | MK-869,MK-0869,L-754030,Aprepitant` | HIV Protease , Antibacterial , Antibiotic , Neurokinin receptor |
Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and C... | |||
T25616 | Lanepitant 2HCl | LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride | Neurokinin receptor |
Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist with analgesic and anti-inflammatory activity.Lanepitant 2HCl inhibits the binding of Substance P to the neurokinin-1 receptor, inhibits neurogenic inflam... | |||
T3716 | Rolapitant | SCH619734 | Neurokinin receptor |
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ... | |||
T76446 | (D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P | ||
(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK 1 receptor antagonist [1] . | |||
T76405 | [D-Trp2,7,9] Substance P | ||
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist that exhibits inhibitory affinities (K_i values) of 1 μM for NK-1, 1.3 μM for NK-2, and approximately 9 μM for NK-3 receptors [1]. | |||
T76427 | (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B | ||
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B functions as a competitive antagonist to the Neurokinin B receptor, exhibiting a pA2 value of 5.5. Notably, it does not affect Substance P or Neurokinin A [1]. | |||
T70456 | Nolpitantium Free Base | ||
Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal s... | |||
T29186 | YM49598 | YM-49598,YM 49598 | |
YM49598 is a tachykinin receptor antagonist. YM49598 exhibited high binding affinities at NK(1) (pK(i) = 9.09 +/- 0.02) and NK(2) (pK(i) = 9.94 +/- 0.03) receptors, respectively. YM49598 was almost inactive but produced ... | |||
T75837 | Spantide I TFA | ||
Spantide I TFA, a selective NK1 receptor antagonist and a substance P analog, exhibits K(i) values of 230 nM for NK1 and 8150 nM for NK2 receptors, respectively. It offers a method to decrease type 1 while increasing typ... | |||
T38276 | Benzomalvin C | ||
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50... | |||
T68371 | Rolapitant hydrochloride hydrate | ||
Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant compe... |